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Integrated Analysis of Residue Coevolution and Protein Structures Capture Key Protein Sectors in HIV-1 Proteins

HIV type 1 (HIV-1) is characterized by its rapid genetic evolution, leading to challenges in anti-HIV therapy. However, the sequence variations in HIV-1 proteins are not randomly distributed due to a combination of functional constraints and genetic drift. In this study, we examined patterns of sequ...

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Detalles Bibliográficos
Autores principales: Zhao, Yuqi, Wang, Yanjie, Gao, Yuedong, Li, Gonghua, Huang, Jingfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324911/
https://www.ncbi.nlm.nih.gov/pubmed/25671429
http://dx.doi.org/10.1371/journal.pone.0117506