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A Fatal Combination: A Thymidylate Synthase Inhibitor with DNA Damaging Activity
2′-deoxy-5-ethynyluridine (EdU) has been previously shown to be a cell poison whose toxicity depends on the particular cell line. The reason is not known. Our data indicates that different efficiency of EdU incorporation plays an important role. The EdU-mediated toxicity was elevated by the inhibiti...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4324964/ https://www.ncbi.nlm.nih.gov/pubmed/25671308 http://dx.doi.org/10.1371/journal.pone.0117459 |