Distinct conformational and functional effects of two adjacent pathogenic mutations in cardiac troponin I at the interface with troponin T

The α-helix in troponin I (TnI) at the interface with troponin T (TnT) is a highly conserved structure. A point mutation in this region, A116G, was found in human cardiac TnI in a case of cardiomyopathy. An adjacent dominantly negative mutation found in turkey cardiac TnI (R111C, equivalent to K117C...

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Detalles Bibliográficos
Autores principales: Akhter, Shirin, Jin, J.-P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325132/
https://www.ncbi.nlm.nih.gov/pubmed/25685665
http://dx.doi.org/10.1016/j.fob.2015.01.001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325132/
https://www.ncbi.nlm.nih.gov/pubmed/25685665
http://dx.doi.org/10.1016/j.fob.2015.01.001

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