EZH2 Protects Glioma Stem Cells from Radiation-Induced Cell Death in a MELK/FOXM1-Dependent Manner

Glioblastoma (GBM)-derived tumorigenic stem-like cells (GSCs) may play a key role in therapy resistance. Previously, we reported that the mitotic kinase MELK binds and phosphorylates the oncogenic transcription factor FOXM1 in GSCs. Here, we demonstrate that the catalytic subunit of Polycomb repress...

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Detalles Bibliográficos
Autores principales: Kim, Sung-Hak, Joshi, Kaushal, Ezhilarasan, Ravesanker, Myers, Toshia R., Siu, Jason, Gu, Chunyu, Nakano-Okuno, Mariko, Taylor, David, Minata, Mutsuko, Sulman, Erik P., Lee, Jeongwu, Bhat, Krishna P.L., Salcini, Anna Elisabetta, Nakano, Ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325196/
https://www.ncbi.nlm.nih.gov/pubmed/25601206
http://dx.doi.org/10.1016/j.stemcr.2014.12.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4325196/
https://www.ncbi.nlm.nih.gov/pubmed/25601206
http://dx.doi.org/10.1016/j.stemcr.2014.12.006

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