Structural biology of presenilin 1 complexes

The presenilin genes were first identified as the site of missense mutations causing early onset autosomal dominant familial Alzheimer's disease. Subsequent work has shown that the presenilin proteins are the catalytic subunits of a hetero-tetrameric complex containing APH1, nicastrin and PEN-2...

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Detalles Bibliográficos
Autores principales: Li, Yi, Bohm, Christopher, Dodd, Roger, Chen, Fusheng, Qamar, Seema, Schmitt-Ulms, Gerold, Fraser, Paul E, St George-Hyslop, Peter H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326451/
https://www.ncbi.nlm.nih.gov/pubmed/25523933
http://dx.doi.org/10.1186/1750-1326-9-59

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326451/
https://www.ncbi.nlm.nih.gov/pubmed/25523933
http://dx.doi.org/10.1186/1750-1326-9-59

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