Antihelminthic benzimidazoles potentiate navitoclax (ABT-263) activity by inducing Noxa-dependent apoptosis in non-small cell lung cancer (NSCLC) cell lines

BACKGROUND: Evasion of apoptosis is a hallmark of cancer cells. One mechanism to deregulate the apoptotic pathway is by upregulation of the anti-apoptotic Bcl-2 family members. Navitoclax (ABT-263) is a Bcl-2/Bcl-x(L) inhibitor that restores the ability of cancer cells to undergo apoptosis. METHODS:...

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Detalles Bibliográficos
Autores principales: Lam, Lloyd T, Zhang, Haichao, Xue, John, Leverson, Joel D, Bhathena, Anahita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Primary Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326508/
https://www.ncbi.nlm.nih.gov/pubmed/25685063
http://dx.doi.org/10.1186/s12935-014-0151-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326508/
https://www.ncbi.nlm.nih.gov/pubmed/25685063
http://dx.doi.org/10.1186/s12935-014-0151-3

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