Cargando…

Type II Cytokines Impair Host Defense Against Intracellular Fungal Pathogen by Amplifying Macrophage Generation of IL-33

IL-4 subverts protective immunity to multiple intracellular pathogens including the fungus Histoplasma capsulatum. Previously, we reported that H. capsulatum-challenged CCR2(−/−) mice manifest elevated pulmonary fungal burden due to exaggerated IL-4. Paradoxical to our anticipation in IL-33 driving...

Descripción completa

Detalles Bibliográficos
Autores principales: Verma, Akash, Kroetz, Danielle N., Tweedle, Jamie L., Deepe, George S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326567/
https://www.ncbi.nlm.nih.gov/pubmed/25118166
http://dx.doi.org/10.1038/mi.2014.75