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Type II Cytokines Impair Host Defense Against Intracellular Fungal Pathogen by Amplifying Macrophage Generation of IL-33
IL-4 subverts protective immunity to multiple intracellular pathogens including the fungus Histoplasma capsulatum. Previously, we reported that H. capsulatum-challenged CCR2(−/−) mice manifest elevated pulmonary fungal burden due to exaggerated IL-4. Paradoxical to our anticipation in IL-33 driving...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326567/ https://www.ncbi.nlm.nih.gov/pubmed/25118166 http://dx.doi.org/10.1038/mi.2014.75 |