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Type II Cytokines Impair Host Defense Against Intracellular Fungal Pathogen by Amplifying Macrophage Generation of IL-33

IL-4 subverts protective immunity to multiple intracellular pathogens including the fungus Histoplasma capsulatum. Previously, we reported that H. capsulatum-challenged CCR2(−/−) mice manifest elevated pulmonary fungal burden due to exaggerated IL-4. Paradoxical to our anticipation in IL-33 driving...

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Detalles Bibliográficos
Autores principales:	Verma, Akash, Kroetz, Danielle N., Tweedle, Jamie L., Deepe, George S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326567/ https://www.ncbi.nlm.nih.gov/pubmed/25118166 http://dx.doi.org/10.1038/mi.2014.75

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