Collagenase-resistant collagen promotes mouse aging and vascular cell senescence

Collagen fibrils become resistant to cleavage over time. We hypothesized that resistance to type I collagen proteolysis not only marks biological aging but also drives it. To test this, we followed mice with a targeted mutation (Col1a1(r/r)) that yields collagenase-resistant type I collagen. Compare...

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Detalles Bibliográficos
Autores principales: Vafaie, Faran, Yin, Hao, O’Neil, Caroline, Nong, Zengxuan, Watson, Alanna, Arpino, John-Michael, Chu, Michael W A, Wayne Holdsworth, David, Gros, Robert, Pickering, J Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326859/
https://www.ncbi.nlm.nih.gov/pubmed/23957394
http://dx.doi.org/10.1111/acel.12155

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326859/
https://www.ncbi.nlm.nih.gov/pubmed/23957394
http://dx.doi.org/10.1111/acel.12155

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