Longevity effect of IGF-1R(+/−) mutation depends on genetic background-specific receptor activation

Growth hormone (GH) and insulin-like growth factor (IGF) signaling regulates lifespan in mice. The modulating effects of genetic background gained much attention because it was shown that life-prolonging effects in Snell dwarf and GH receptor knockout vary between mouse strains. We previously report...

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Detalles Bibliográficos
Autores principales: Xu, Jie, Gontier, Géraldine, Chaker, Zayna, Lacube, Philippe, Dupont, Joëlle, Holzenberger, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326867/
https://www.ncbi.nlm.nih.gov/pubmed/23898955
http://dx.doi.org/10.1111/acel.12145

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326867/
https://www.ncbi.nlm.nih.gov/pubmed/23898955
http://dx.doi.org/10.1111/acel.12145

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