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The aging signature: a hallmark of induced pluripotent stem cells?

The discovery that somatic cells can be induced into a pluripotent state by the expression of reprogramming factors has enormous potential for therapeutics and human disease modeling. With regard to aging and rejuvenation, the reprogramming process resets an aged, somatic cell to a more youthful sta...

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Detalles Bibliográficos
Autores principales: Rohani, Leili, Johnson, Adiv A, Arnold, Antje, Stolzing, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326871/
https://www.ncbi.nlm.nih.gov/pubmed/24256351
http://dx.doi.org/10.1111/acel.12182
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author Rohani, Leili
Johnson, Adiv A
Arnold, Antje
Stolzing, Alexandra
author_facet Rohani, Leili
Johnson, Adiv A
Arnold, Antje
Stolzing, Alexandra
author_sort Rohani, Leili
collection PubMed
description The discovery that somatic cells can be induced into a pluripotent state by the expression of reprogramming factors has enormous potential for therapeutics and human disease modeling. With regard to aging and rejuvenation, the reprogramming process resets an aged, somatic cell to a more youthful state, elongating telomeres, rearranging the mitochondrial network, reducing oxidative stress, restoring pluripotency, and making numerous other alterations. The extent to which induced pluripotent stem cell (iPSC)s mime embryonic stem cells is controversial, however, as iPSCs have been shown to harbor an epigenetic memory characteristic of their tissue of origin which may impact their differentiation potential. Furthermore, there are contentious data regarding the extent to which telomeres are elongated, telomerase activity is reconstituted, and mitochondria are reorganized in iPSCs. Although several groups have reported that reprogramming efficiency declines with age and is inhibited by genes upregulated with age, others have successfully generated iPSCs from senescent and centenarian cells. Mixed findings have also been published regarding whether somatic cells generated from iPSCs are subject to premature senescence. Defects such as these would hinder the clinical application of iPSCs, and as such, more comprehensive testing of iPSCs and their potential aging signature should be conducted.
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spelling pubmed-43268712015-02-19 The aging signature: a hallmark of induced pluripotent stem cells? Rohani, Leili Johnson, Adiv A Arnold, Antje Stolzing, Alexandra Aging Cell Review The discovery that somatic cells can be induced into a pluripotent state by the expression of reprogramming factors has enormous potential for therapeutics and human disease modeling. With regard to aging and rejuvenation, the reprogramming process resets an aged, somatic cell to a more youthful state, elongating telomeres, rearranging the mitochondrial network, reducing oxidative stress, restoring pluripotency, and making numerous other alterations. The extent to which induced pluripotent stem cell (iPSC)s mime embryonic stem cells is controversial, however, as iPSCs have been shown to harbor an epigenetic memory characteristic of their tissue of origin which may impact their differentiation potential. Furthermore, there are contentious data regarding the extent to which telomeres are elongated, telomerase activity is reconstituted, and mitochondria are reorganized in iPSCs. Although several groups have reported that reprogramming efficiency declines with age and is inhibited by genes upregulated with age, others have successfully generated iPSCs from senescent and centenarian cells. Mixed findings have also been published regarding whether somatic cells generated from iPSCs are subject to premature senescence. Defects such as these would hinder the clinical application of iPSCs, and as such, more comprehensive testing of iPSCs and their potential aging signature should be conducted. BlackWell Publishing Ltd 2014-02 2013-11-21 /pmc/articles/PMC4326871/ /pubmed/24256351 http://dx.doi.org/10.1111/acel.12182 Text en © 2013 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Rohani, Leili
Johnson, Adiv A
Arnold, Antje
Stolzing, Alexandra
The aging signature: a hallmark of induced pluripotent stem cells?
title The aging signature: a hallmark of induced pluripotent stem cells?
title_full The aging signature: a hallmark of induced pluripotent stem cells?
title_fullStr The aging signature: a hallmark of induced pluripotent stem cells?
title_full_unstemmed The aging signature: a hallmark of induced pluripotent stem cells?
title_short The aging signature: a hallmark of induced pluripotent stem cells?
title_sort aging signature: a hallmark of induced pluripotent stem cells?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326871/
https://www.ncbi.nlm.nih.gov/pubmed/24256351
http://dx.doi.org/10.1111/acel.12182
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