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The aging signature: a hallmark of induced pluripotent stem cells?
The discovery that somatic cells can be induced into a pluripotent state by the expression of reprogramming factors has enormous potential for therapeutics and human disease modeling. With regard to aging and rejuvenation, the reprogramming process resets an aged, somatic cell to a more youthful sta...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326871/ https://www.ncbi.nlm.nih.gov/pubmed/24256351 http://dx.doi.org/10.1111/acel.12182 |
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author | Rohani, Leili Johnson, Adiv A Arnold, Antje Stolzing, Alexandra |
author_facet | Rohani, Leili Johnson, Adiv A Arnold, Antje Stolzing, Alexandra |
author_sort | Rohani, Leili |
collection | PubMed |
description | The discovery that somatic cells can be induced into a pluripotent state by the expression of reprogramming factors has enormous potential for therapeutics and human disease modeling. With regard to aging and rejuvenation, the reprogramming process resets an aged, somatic cell to a more youthful state, elongating telomeres, rearranging the mitochondrial network, reducing oxidative stress, restoring pluripotency, and making numerous other alterations. The extent to which induced pluripotent stem cell (iPSC)s mime embryonic stem cells is controversial, however, as iPSCs have been shown to harbor an epigenetic memory characteristic of their tissue of origin which may impact their differentiation potential. Furthermore, there are contentious data regarding the extent to which telomeres are elongated, telomerase activity is reconstituted, and mitochondria are reorganized in iPSCs. Although several groups have reported that reprogramming efficiency declines with age and is inhibited by genes upregulated with age, others have successfully generated iPSCs from senescent and centenarian cells. Mixed findings have also been published regarding whether somatic cells generated from iPSCs are subject to premature senescence. Defects such as these would hinder the clinical application of iPSCs, and as such, more comprehensive testing of iPSCs and their potential aging signature should be conducted. |
format | Online Article Text |
id | pubmed-4326871 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BlackWell Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-43268712015-02-19 The aging signature: a hallmark of induced pluripotent stem cells? Rohani, Leili Johnson, Adiv A Arnold, Antje Stolzing, Alexandra Aging Cell Review The discovery that somatic cells can be induced into a pluripotent state by the expression of reprogramming factors has enormous potential for therapeutics and human disease modeling. With regard to aging and rejuvenation, the reprogramming process resets an aged, somatic cell to a more youthful state, elongating telomeres, rearranging the mitochondrial network, reducing oxidative stress, restoring pluripotency, and making numerous other alterations. The extent to which induced pluripotent stem cell (iPSC)s mime embryonic stem cells is controversial, however, as iPSCs have been shown to harbor an epigenetic memory characteristic of their tissue of origin which may impact their differentiation potential. Furthermore, there are contentious data regarding the extent to which telomeres are elongated, telomerase activity is reconstituted, and mitochondria are reorganized in iPSCs. Although several groups have reported that reprogramming efficiency declines with age and is inhibited by genes upregulated with age, others have successfully generated iPSCs from senescent and centenarian cells. Mixed findings have also been published regarding whether somatic cells generated from iPSCs are subject to premature senescence. Defects such as these would hinder the clinical application of iPSCs, and as such, more comprehensive testing of iPSCs and their potential aging signature should be conducted. BlackWell Publishing Ltd 2014-02 2013-11-21 /pmc/articles/PMC4326871/ /pubmed/24256351 http://dx.doi.org/10.1111/acel.12182 Text en © 2013 The Authors. Aging Cell published by the Anatomical Society and John Wiley & Sons Ltd. http://creativecommons.org/licenses/by/3.0/ This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Rohani, Leili Johnson, Adiv A Arnold, Antje Stolzing, Alexandra The aging signature: a hallmark of induced pluripotent stem cells? |
title | The aging signature: a hallmark of induced pluripotent stem cells? |
title_full | The aging signature: a hallmark of induced pluripotent stem cells? |
title_fullStr | The aging signature: a hallmark of induced pluripotent stem cells? |
title_full_unstemmed | The aging signature: a hallmark of induced pluripotent stem cells? |
title_short | The aging signature: a hallmark of induced pluripotent stem cells? |
title_sort | aging signature: a hallmark of induced pluripotent stem cells? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326871/ https://www.ncbi.nlm.nih.gov/pubmed/24256351 http://dx.doi.org/10.1111/acel.12182 |
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