Lifelong treatment with atenolol decreases membrane fatty acid unsaturation and oxidative stress in heart and skeletal muscle mitochondria and improves immunity and behavior, without changing mice longevity

The membrane fatty acid unsaturation hypothesis of aging and longevity is experimentally tested for the first time in mammals. Lifelong treatment of mice with the β1-blocker atenolol increased the amount of the extracellular-signal-regulated kinase signaling protein and successfully decreased one of...

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Detalles Bibliográficos
Autores principales: Gómez, Alexia, Sánchez-Roman, Ines, Gomez, Jose, Cruces, Julia, Mate, Ianire, Lopez-Torres, Mónica, Naudi, Alba, Portero-Otin, Manuel, Pamplona, Reinald, De la Fuente, Monica, Barja, Gustavo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326892/
https://www.ncbi.nlm.nih.gov/pubmed/24612513
http://dx.doi.org/10.1111/acel.12205

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326892/
https://www.ncbi.nlm.nih.gov/pubmed/24612513
http://dx.doi.org/10.1111/acel.12205

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