Senescence-secreted factors activate Myc and sensitize pretransformed cells to TRAIL-induced apoptosis

Senescent cells secrete a plethora of factors with potent paracrine signaling capacity. Strikingly, senescence, which acts as defense against cell transformation, exerts pro-tumorigenic activities through its secretome by promoting tumor-specific features, such as cellular proliferation, epithelial-...

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Detalles Bibliográficos
Autores principales: Vjetrovic, Jelena, Shankaranarayanan, Pattabhiraman, Mendoza-Parra, Marco A, Gronemeyer, Hinrich
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326894/
https://www.ncbi.nlm.nih.gov/pubmed/24589226
http://dx.doi.org/10.1111/acel.12197

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326894/
https://www.ncbi.nlm.nih.gov/pubmed/24589226
http://dx.doi.org/10.1111/acel.12197

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