Reversible cell cycle inhibition and premature aging features imposed by conditional expression of p16(Ink4a)

The cyclin-dependent kinase (Cdk) inhibitor p16(Ink4a) (p16) is a canonical mediator of cellular senescence and accumulates in aging tissues, where it constrains proliferation of some progenitor cells. However, whether p16 induction in tissues is sufficient to inhibit cell proliferation, mediate sen...

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Detalles Bibliográficos
Autores principales: Boquoi, Amelie, Arora, Sanjeevani, Chen, Tina, Litwin, Sam, Koh, James, Enders, Greg H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326901/
https://www.ncbi.nlm.nih.gov/pubmed/25481981
http://dx.doi.org/10.1111/acel.12279

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326901/
https://www.ncbi.nlm.nih.gov/pubmed/25481981
http://dx.doi.org/10.1111/acel.12279

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