Neuronal protein with tau-like repeats (PTL-1) regulates intestinal SKN-1 nuclear accumulation in response to oxidative stress

Oxidative stress is a central pathomechanism in Alzheimer's disease (AD) and other diseases with tau pathology. The Nrf2 transcription factor induces detoxification enzymes and improves tau pathology and cognition. Its homologue in C. elegans is SKN-1. We previously showed that the worm tau hom...

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Detalles Bibliográficos
Autores principales: Chew, Yee Lian, Götz, Jürgen, Nicholas, Hannah R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Short Take
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326904/
https://www.ncbi.nlm.nih.gov/pubmed/25399685
http://dx.doi.org/10.1111/acel.12285

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326904/
https://www.ncbi.nlm.nih.gov/pubmed/25399685
http://dx.doi.org/10.1111/acel.12285

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