Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes

Age-dependent neurodegenerative diseases progressively form aggregates containing both shared components (e.g., TDP-43, phosphorylated tau) and proteins specific to each disease. We investigated whether diverse neuropathies might have additional aggregation-prone proteins in common, discoverable by...

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Detalles Bibliográficos
Autores principales: Ayyadevara, Srinivas, Balasubramaniam, Meenakshisundaram, Gao, Yuan, Yu, Li-Rong, Alla, Ramani, Shmookler Reis, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326912/
https://www.ncbi.nlm.nih.gov/pubmed/25510159
http://dx.doi.org/10.1111/acel.12296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326912/
https://www.ncbi.nlm.nih.gov/pubmed/25510159
http://dx.doi.org/10.1111/acel.12296

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