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Proteins in aggregates functionally impact multiple neurodegenerative disease models by forming proteasome-blocking complexes

Age-dependent neurodegenerative diseases progressively form aggregates containing both shared components (e.g., TDP-43, phosphorylated tau) and proteins specific to each disease. We investigated whether diverse neuropathies might have additional aggregation-prone proteins in common, discoverable by...

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Detalles Bibliográficos
Autores principales:	Ayyadevara, Srinivas, Balasubramaniam, Meenakshisundaram, Gao, Yuan, Yu, Li-Rong, Alla, Ramani, Shmookler Reis, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2015
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326912/ https://www.ncbi.nlm.nih.gov/pubmed/25510159 http://dx.doi.org/10.1111/acel.12296

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