Methionine restriction slows down senescence in human diploid fibroblasts

Methionine restriction (MetR) extends lifespan in animal models including rodents. Using human diploid fibroblasts (HDF), we report here that MetR significantly extends their replicative lifespan, thereby postponing cellular senescence. MetR significantly decreased activity of mitochondrial complex...

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Detalles Bibliográficos
Autores principales: Kozieł, Rafał, Ruckenstuhl, Christoph, Albertini, Eva, Neuhaus, Michael, Netzberger, Christine, Bust, Maria, Madeo, Frank, Wiesner, Rudolf J, Jansen-Dürr, Pidder
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326930/
https://www.ncbi.nlm.nih.gov/pubmed/25273919
http://dx.doi.org/10.1111/acel.12266

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326930/
https://www.ncbi.nlm.nih.gov/pubmed/25273919
http://dx.doi.org/10.1111/acel.12266

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