Essential role for the TRF2 telomere protein in adult skin homeostasis

TRF2 is a component of shelterin, the protein complex that protects the ends of mammalian chromosomes. TRF2 is essential for telomere capping owing to its roles in suppressing an ATM-dependent DNA damage response (DDR) at chromosome ends and inhibiting end-to-end chromosome fusions. Mice deficient f...

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Detalles Bibliográficos
Autores principales: Martínez, Paula, Ferrara-Romeo, Iole, Flores, Juana M, Blasco, Maria A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326939/
https://www.ncbi.nlm.nih.gov/pubmed/24725274
http://dx.doi.org/10.1111/acel.12221

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4326939/
https://www.ncbi.nlm.nih.gov/pubmed/24725274
http://dx.doi.org/10.1111/acel.12221

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