Superoxide Inhibits Guanine Nucleotide Exchange Factor (GEF) Action on Ras, but not on Rho, through Desensitization of Ras to GEF

[Image: see text] Ras and Rho GTPases are molecular switches for various vital cellular signaling pathways. Overactivation of these GTPases often causes development of cancer. Guanine nucleotide exchange factors (GEFs) and oxidants function to upregulate these GTPases through facilitation of guanine...

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Detalles Bibliográficos
Autores principales: Wey, Michael, Phan, Vinh, Yepez, Gerardo, Heo, Jongyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327825/
https://www.ncbi.nlm.nih.gov/pubmed/24422478
http://dx.doi.org/10.1021/bi401528n

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327825/
https://www.ncbi.nlm.nih.gov/pubmed/24422478
http://dx.doi.org/10.1021/bi401528n

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