Cargando…

Superoxide Inhibits Guanine Nucleotide Exchange Factor (GEF) Action on Ras, but not on Rho, through Desensitization of Ras to GEF

[Image: see text] Ras and Rho GTPases are molecular switches for various vital cellular signaling pathways. Overactivation of these GTPases often causes development of cancer. Guanine nucleotide exchange factors (GEFs) and oxidants function to upregulate these GTPases through facilitation of guanine...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wey, Michael, Phan, Vinh, Yepez, Gerardo, Heo, Jongyun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327825/ https://www.ncbi.nlm.nih.gov/pubmed/24422478 http://dx.doi.org/10.1021/bi401528n

Ejemplares similares

Quantitative Analysis of Guanine Nucleotide Exchange Factors (GEFs) as Enzymes
por: Randazzo, Paul A, et al.
Publicado: (2014)

Regulation and functions of the RhoA regulatory guanine nucleotide exchange factor GEF-H1
por: Joo, Emily, et al.
Publicado: (2020)

The Interplay between the Escherichia coli Rho Guanine Nucleotide Exchange Factor Effectors and the Mammalian RhoGEF Inhibitor EspH
por: Wong, Alexander R. C., et al.
Publicado: (2012)

The Rho-guanine nucleotide exchange factor PDZ-RhoGEF governs susceptibility to diet-induced obesity and type 2 diabetes
por: Chang, Ying-Ju, et al.
Publicado: (2015)

Anthraquinones as Inhibitors of SOS RAS-GEF Activity
por: Fernández-Medarde, Alberto, et al.
Publicado: (2021)

The Rho Guanine Nucleotide Exchange Factor DRhoGEF2 Is a Genetic Modifier of the PI3K Pathway in Drosophila
por: Chang, Ying-Ju, et al.
Publicado: (2016)

Linking Ras to myosin function: RasGEF Q, a Dictyostelium exchange factor for RasB, affects myosin II functions
por: Mondal, Subhanjan, et al.
Publicado: (2008)

On the mechanism of autoinhibition of the RhoA-specific nucleotide exchange factor PDZRhoGEF
por: Zheng, Meiying, et al.
Publicado: (2009)

Correction: The Rho Guanine Nucleotide Exchange Factor DRhoGEF2 Is a Genetic Modifier of the PI3K Pathway in Drosophila
por: Chang, Ying-Ju, et al.
Publicado: (2021)

A novel Dictyostelium RasGEF required for chemotaxis and development
por: Arigoni, Maddalena, et al.
Publicado: (2005)

Expression of the Rap1 Guanine Nucleotide Exchange Factor, MR-GEF, Is Altered in Individuals with Bipolar Disorder
por: Bithell, Angela, et al.
Publicado: (2010)

The Dictyostelium genome encodes numerous RasGEFs with multiple biological roles
por: Wilkins, Andrew, et al.
Publicado: (2005)

Conserved role of Ras-GEFs in promoting aging: from yeast to mice
por: Mirisola, Mario G., et al.
Publicado: (2011)

Expression of a RhoA-Specific Guanine Nucleotide Exchange Factor, p190RhoGEF, in Mouse Macrophages Negatively Affects M1 Polarization and Inflammatory Responses
por: Choi, So-Yeon, et al.
Publicado: (2022)

The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins
por: Guilluy, Christophe, et al.
Publicado: (2011)

I’m coming to GEF you: Regulation of RhoGEFs during cell migration
por: Goicoechea, Silvia M, et al.
Publicado: (2014)

Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission
por: Martz, Matthew K., et al.
Publicado: (2013)

Tension on JAM-A activates RhoA via GEF-H1 and p115 RhoGEF
por: Scott, David W., et al.
Publicado: (2016)

Rho Family GTPases and Rho GEFs in Glucose Homeostasis
por: Machin, Polly A., et al.
Publicado: (2021)

Structure analysis between the SWAP-70 RHO-GEF and the newly described PLD2-GEF
por: Gomez-Cambronero, Julian
Publicado: (2012)

Autophagy suppresses cell migration by degrading GEF-H1, a RhoA GEF
por: Yoshida, Tatsushi, et al.
Publicado: (2016)

The Rho-GEF Gef3 interacts with the septin complex and activates the GTPase Rho4 during fission yeast cytokinesis
por: Wang, Ning, et al.
Publicado: (2015)

The expression and prognostic value of the guanine nucleotide exchange factors (GEFs) Trio, Vav1 and TIAM-1 in human breast cancer
por: Lane, Jane, et al.
Publicado: (2008)

Guanine Nucleotide Exchange Factor 7B (RopGEF7B) is involved in floral organ development in Oryza sativa
por: Huang, Jiaqing, et al.
Publicado: (2018)

In Drosophila, RhoGEF2 cooperates with activated Ras in tumorigenesis through a pathway involving Rho1–Rok–Myosin-II and JNK signalling
por: Khoo, Peytee, et al.
Publicado: (2013)

Nucleotide exchange factors: Kinetic analyses and the rationale for studying kinetics of GEFs
por: Northup, John K., et al.
Publicado: (2012)

Critical requirement of SOS1 RAS-GEF function for mitochondrial dynamics, metabolism, and redox homeostasis
por: García-Navas, Rósula, et al.
Publicado: (2021)

Very-KIND, a KIND domain–containing RasGEF, controls dendrite growth by linking Ras small GTPases and MAP2
por: Huang, Jinhong, et al.
Publicado: (2007)

Obscurin Rho GEF domains are phosphorylated by MST-family kinases but do not exhibit nucleotide exchange factor activity towards Rho GTPases in vitro
por: Koch, Daniel, et al.
Publicado: (2023)

A Histidine pH sensor regulates activation of the Ras-specific guanine nucleotide exchange factor RasGRP1
por: Vercoulen, Yvonne, et al.
Publicado: (2017)

Divergence of Rho residue 43 impacts GEF activity
por: Sloan, Christina M., et al.
Publicado: (2012)

Roles of putative Rho-GEF Gef2 in division-site positioning and contractile-ring function in fission yeast cytokinesis
por: Ye, Yanfang, et al.
Publicado: (2012)

Cooperation between Rho-GEF Gef2 and its binding partner Nod1 in the regulation of fission yeast cytokinesis
por: Zhu, Yi-Hua, et al.
Publicado: (2013)

The human Rgr oncogene is overexpressed in T cell malignancies and induces transformation by acting as a GEF for Ras and Ral
por: Osei-Sarfo, Kwame, et al.
Publicado: (2011)

Transcriptomic analysis of the role of RasGEF1B circular RNA in the TLR4/LPS pathway
por: Ng, Wei Lun, et al.
Publicado: (2017)

The Ras guanine nucleotide exchange factor RasGRF1 promotes matrix metalloproteinase-3 production in rheumatoid arthritis synovial tissue
por: Abreu, Joana RF, et al.
Publicado: (2009)

TC-PTP Dephosphorylates the Guanine Nucleotide Exchange Factor C3G (RapGEF1) and Negatively Regulates Differentiation of Human Neuroblastoma Cells
por: Mitra, Aninda, et al.
Publicado: (2011)

Rho GTPase–independent regulation of mitotic progression by the RhoGEF Net1
por: Menon, Sarita, et al.
Publicado: (2013)

Turning Platelets Off and On: Role of RhoGAPs and RhoGEFs in Platelet Activity
por: Comer, Shane P.
Publicado: (2022)

Rho GAPs and GEFs: Controling switches in endothelial cell adhesion
por: van Buul, Jaap D, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_gvm4u5ecqmdk35ds3uef7me1f3