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Apolipoprotein E promotes subretinal mononuclear phagocyte survival and chronic inflammation in age-related macular degeneration
Physiologically, the retinal pigment epithelium (RPE) expresses immunosuppressive signals such as FAS ligand (FASL), which prevents the accumulation of leukocytes in the subretinal space. Age-related macular degeneration (AMD) is associated with a breakdown of the subretinal immunosuppressive enviro...
Autores principales: | Levy, Olivier, Calippe, Bertrand, Lavalette, Sophie, Hu, Shulong J, Raoul, William, Dominguez, Elisa, Housset, Michael, Paques, Michel, Sahel, José-Alain, Bemelmans, Alexis-Pierre, Combadiere, Christophe, Guillonneau, Xavier, Sennlaub, Florian |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4328649/ https://www.ncbi.nlm.nih.gov/pubmed/25604058 http://dx.doi.org/10.15252/emmm.201404524 |
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