Vismodegib, an antagonist of hedgehog signaling, directly alters taste molecular signaling in taste buds

Vismodegib, a highly selective inhibitor of hedgehog (Hh) pathway, is an approved treatment for basal-cell carcinoma. Patients on treatment with vismodegib often report profound alterations in taste sensation. The cellular mechanisms underlying the alterations have not been studied. Sonic Hh (Shh) s...

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Detalles Bibliográficos
Autores principales: Yang, Hyekyung, Cong, Wei-na, Yoon, Jeong Seon, Egan, Josephine M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2015
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329008/
https://www.ncbi.nlm.nih.gov/pubmed/25354792
http://dx.doi.org/10.1002/cam4.350

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329008/
https://www.ncbi.nlm.nih.gov/pubmed/25354792
http://dx.doi.org/10.1002/cam4.350

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