Augmented efficacy with the combination of blockade of the NOTCH-1 pathway, Bortezomib and Romidepsin in a murine MT-1 adult T cell leukemia model

Adult T-cell leukemia (ATL) is an aggressive malignancy caused by human T-cell lymphotropic virus I (HTLV-1). There is no accepted curative therapy for ATL. We have reported that certain ATL patients have increased Notch-1 signaling along with constitutive activation of the NF-κB pathway. Physical a...

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Detalles Bibliográficos
Autores principales: Yu, Ping, Petrus, Michael N., Ju, Wei, Zhang, Meili, Conlon, Kevin C., Nakagawa, Masao, Maeda, Michiyuki, Bamford, Richard N., Waldmann, Thomas A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329116/
https://www.ncbi.nlm.nih.gov/pubmed/25118879
http://dx.doi.org/10.1038/leu.2014.241

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329116/
https://www.ncbi.nlm.nih.gov/pubmed/25118879
http://dx.doi.org/10.1038/leu.2014.241

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