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The case of triethylammonium cation loss during purification of certain nucleotide analogues: a cautionary note

Nucleotides, their analogues, and other phosphate esters and phosphoramidates often contain the triethylammonium cation as a counterion. We found that this may be lost during chromatographic purification or concentration of solutions, yielding products in acidic forms or containing sub-stoichiometri...

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Detalles Bibliográficos
Autores principales: Kolodziej, Krystian, Romanowska, Joanna, Stawinski, Jacek, Kraszewski, Adam, Sobkowski, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329187/
https://www.ncbi.nlm.nih.gov/pubmed/25542580
http://dx.doi.org/10.1007/s00216-014-8397-0