Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase

[Image: see text] Selective inhibition of neuronal nitric oxide synthase (nNOS) is an important therapeutic approach to target neurodegenerative disorders. However, the majority of the nNOS inhibitors developed are arginine mimetics and, therefore, suffer from poor bioavailability. We designed a nov...

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Detalles Bibliográficos
Autores principales: Mukherjee, Paramita, Li, Huiying, Sevrioukova, Irina, Chreifi, Georges, Martásek, Pavel, Roman, Linda J., Poulos, Thomas L., Silverman, Richard B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329833/
https://www.ncbi.nlm.nih.gov/pubmed/25489882
http://dx.doi.org/10.1021/jm501719e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329833/
https://www.ncbi.nlm.nih.gov/pubmed/25489882
http://dx.doi.org/10.1021/jm501719e

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