Serum Alanine Transaminase Total Bilirubin Concentrations Predict CYP3A Activity as Measured by Midazolam and 1′-Hydroxylation

BACKGROUND: Microsomal enzyme P450 (CYP450) plays an important role in metabolism of most xenobiotics. The activity of CYP3A decreases in patients with liver dysfunction. However, whether serum concentrations of liver enzymes reflect the activity of CYP3A is unclear. We aimed to search for a new clu...

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Detalles Bibliográficos
Autores principales: He, Rui, Li, Yuhong, Ruan, Jinguang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2015
Materias:
Clinical Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329940/
https://www.ncbi.nlm.nih.gov/pubmed/25648948
http://dx.doi.org/10.12659/MSM.892044

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329940/
https://www.ncbi.nlm.nih.gov/pubmed/25648948
http://dx.doi.org/10.12659/MSM.892044

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