Critical Role for Mast Cell Stat5 Activity in Skin Inflammation

Atopic dermatitis (AD) is a chronic inflammatory skin disease. Here, we show that phospholipase C-β3 (PLC-β3)-deficient mice spontaneously develop AD-like skin lesions and more severe allergen-induced dermatitis than wild-type mice. Mast cells were required for both AD models and remarkably increase...

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Detalles Bibliográficos
Autores principales: Ando, Tomoaki, Xiao, Wenbin, Gao, Peisong, Namiranian, Siavash, Matsumoto, Kenji, Tomimori, Yoshiaki, Hong, Hong, Yamashita, Hirotaka, Kimura, Miho, Kashiwakura, Jun-ichi, Hata, Tissa R., Izuhara, Kenji, Gurish, Michael F., Roers, Axel, Rafaels, Nicholas M., Barnes, Kathleen C., Jamora, Colin, Kawakami, Yuko, Kawakami, Toshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329986/
https://www.ncbi.nlm.nih.gov/pubmed/24412367
http://dx.doi.org/10.1016/j.celrep.2013.12.029

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4329986/
https://www.ncbi.nlm.nih.gov/pubmed/24412367
http://dx.doi.org/10.1016/j.celrep.2013.12.029

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