Borreliacidal activity of Borrelia metal transporter A (BmtA) binding small molecules by manganese transport inhibition

Borrelia burgdorferi, the causative agent of Lyme disease, utilizes manganese (Mn) for its various metabolic needs. We hypothesized that blocking Mn transporter could be a possible approach to inhibit metabolic activity of this pathogen and eliminate the infection. We used a combination of in silico...

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Detalles Bibliográficos
Autores principales: Wagh, Dhananjay, Pothineni, Venkata Raveendra, Inayathullah, Mohammed, Liu, Song, Kim, Kwang-Min, Rajadas, Jayakumar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330029/
https://www.ncbi.nlm.nih.gov/pubmed/25709405
http://dx.doi.org/10.2147/DDDT.S77063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330029/
https://www.ncbi.nlm.nih.gov/pubmed/25709405
http://dx.doi.org/10.2147/DDDT.S77063

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