Competitive Binding of a Benzimidazole to the Histone-Binding Pocket of the Pygo PHD Finger

[Image: see text] The Pygo-BCL9 complex is a chromatin reader, facilitating β-catenin-mediated oncogenesis, and is thus emerging as a potential therapeutic target for cancer. Its function relies on two ligand-binding surfaces of Pygo’s PHD finger that anchor the histone H3 tail methylated at lysine...

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Detalles Bibliográficos
Autores principales: Miller, Thomas C. R., Rutherford, Trevor J., Birchall, Kristian, Chugh, Jasveen, Fiedler, Marc, Bienz, Mariann
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330097/
https://www.ncbi.nlm.nih.gov/pubmed/25323450
http://dx.doi.org/10.1021/cb500585s

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330097/
https://www.ncbi.nlm.nih.gov/pubmed/25323450
http://dx.doi.org/10.1021/cb500585s

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