DICER-dependent biogenesis of let-7 miRNAs affects human cell response to DNA damage via targeting p21/p27

Recently, it was reported that knockdown of DICER reduced the ATM-dependent DNA damage response and homologous recombination repair (HRR) via decreasing DICER-generated small RNAs at the damage sites. However, we found that knockdown of DICER dramatically increased cell resistance to camptothecin th...

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Detalles Bibliográficos
Autores principales: Liu, Bailong, Liu, Min, Wang, Jian, Zhang, Xiangming, Wang, Xiang, Wang, Ping, Wang, Hongyan, Li, Wei, Wang, Ya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330351/
https://www.ncbi.nlm.nih.gov/pubmed/25578966
http://dx.doi.org/10.1093/nar/gku1368

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330351/
https://www.ncbi.nlm.nih.gov/pubmed/25578966
http://dx.doi.org/10.1093/nar/gku1368

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