DNA-mediated cooperativity facilitates the co-selection of cryptic enhancer sequences by SOX2 and PAX6 transcription factors

Sox2 and Pax6 are transcription factors that direct cell fate decision during neurogenesis, yet the mechanism behind how they cooperate on enhancer DNA elements and regulate gene expression is unclear. By systematically interrogating Sox2 and Pax6 interaction on minimal enhancer elements, we found t...

Descripción completa

Detalles Bibliográficos
Autores principales: Narasimhan, Kamesh, Pillay, Shubhadra, Huang, Yong-Heng, Jayabal, Sriram, Udayasuryan, Barath, Veerapandian, Veeramohan, Kolatkar, Prasanna, Cojocaru, Vlad, Pervushin, Konstantin, Jauch, Ralf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330359/
https://www.ncbi.nlm.nih.gov/pubmed/25578969
http://dx.doi.org/10.1093/nar/gku1390

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330359/
https://www.ncbi.nlm.nih.gov/pubmed/25578969
http://dx.doi.org/10.1093/nar/gku1390

Ejemplares similares