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Structural insight into how the human helicase subunit MCM2 may act as a histone chaperone together with ASF1 at the replication fork
MCM2 is a subunit of the replicative helicase machinery shown to interact with histones H3 and H4 during the replication process through its N-terminal domain. During replication, this interaction has been proposed to assist disassembly and assembly of nucleosomes on DNA. However, how this interacti...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330383/ https://www.ncbi.nlm.nih.gov/pubmed/25618846 http://dx.doi.org/10.1093/nar/gkv021 |