Global Oct4 target gene analysis reveals novel downstream PTEN and TNC genes required for drug-resistance and metastasis in lung cancer

Overexpression of Oct4, a stemness gene encoding a transcription factor, has been reported in several cancers. However, the mechanism by which Oct4 directs transcriptional program that leads to somatic cancer progression remains unclear. In this study, we provide mechanistic insight into Oct4-driven...

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Detalles Bibliográficos
Autores principales: Tang, Yen-An, Chen, Chi-Hsin, Sun, H. Sunny, Cheng, Chun-Pei, Tseng, Vincent S., Hsu, Han-Shui, Su, Wu-Chou, Lai, Wu-Wei, Wang, Yi-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330385/
https://www.ncbi.nlm.nih.gov/pubmed/25609695
http://dx.doi.org/10.1093/nar/gkv024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330385/
https://www.ncbi.nlm.nih.gov/pubmed/25609695
http://dx.doi.org/10.1093/nar/gkv024

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