Cargando…

Global Oct4 target gene analysis reveals novel downstream PTEN and TNC genes required for drug-resistance and metastasis in lung cancer

Overexpression of Oct4, a stemness gene encoding a transcription factor, has been reported in several cancers. However, the mechanism by which Oct4 directs transcriptional program that leads to somatic cancer progression remains unclear. In this study, we provide mechanistic insight into Oct4-driven...

Descripción completa

Detalles Bibliográficos
Autores principales:	Tang, Yen-An, Chen, Chi-Hsin, Sun, H. Sunny, Cheng, Chun-Pei, Tseng, Vincent S., Hsu, Han-Shui, Su, Wu-Chou, Lai, Wu-Wei, Wang, Yi-Ching
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4330385/ https://www.ncbi.nlm.nih.gov/pubmed/25609695 http://dx.doi.org/10.1093/nar/gkv024

Ejemplares similares

CpG domains downstream of TSSs promote high levels of gene expression
por: Krinner, Simone, et al.
Publicado: (2014)

Ash2l interacts with Oct4-stemness circuitry to promote super-enhancer-driven pluripotency network
por: Tsai, Ping-Hsing, et al.
Publicado: (2019)

Coordinated repressive chromatin-remodeling of Oct4 and Nanog genes in RA-induced differentiation of embryonic stem cells involves RIP140
por: Wu, Cheng-Ying, et al.
Publicado: (2014)

Oct-2 forms a complex with Oct-1 on the iNOS promoter and represses transcription by interfering with recruitment of RNA PolII by Oct-1
por: Bentrari, Fatima, et al.
Publicado: (2015)

Targeted transcriptional activation of silent oct4 pluripotency gene by combining designer TALEs and inhibition of epigenetic modifiers
por: Bultmann, Sebastian, et al.
Publicado: (2012)

Direct activation of human and mouse Oct4 genes using engineered TALE and Cas9 transcription factors
por: Hu, Jiabiao, et al.
Publicado: (2014)

OCT4 interprets and enhances nucleosome flexibility
por: MacCarthy, Caitlin M, et al.
Publicado: (2022)

Profiling of promoter occupancy by the SND1 transcriptional coactivator identifies downstream glycerolipid metabolic genes involved in TNFα response in human hepatoma cells
por: Arretxe, Enara, et al.
Publicado: (2015)

Histone demethylase KDM3A is required for enhancer activation of hippo target genes in colorectal cancer
por: Wang, Hui-Yi, et al.
Publicado: (2019)

Opbp is a new architectural/insulator protein required for ribosomal gene expression
por: Zolotarev, Nikolay, et al.
Publicado: (2017)

Different N-terminal isoforms of Oct-1 control expression of distinct sets of genes and their high levels in Namalwa Burkitt's lymphoma cells affect a wide range of cellular processes
por: Pankratova, Elizaveta V., et al.
Publicado: (2016)

The homeodomain of Oct4 is a dimeric binder of methylated CpG elements
por: Tan, Daisylyn Senna, et al.
Publicado: (2023)

TFIIS is required for the balanced expression of the genes encoding ribosomal components under transcriptional stress
por: Gómez-Herreros, Fernando, et al.
Publicado: (2012)

Repression of a large number of genes requires interplay between homologous recombination and HIRA
por: Misova, Ivana, et al.
Publicado: (2021)

H2B ubiquitylation and the histone chaperone Asf1 cooperatively mediate the formation and maintenance of heterochromatin silencing
por: Wu, Meng-Ying, et al.
Publicado: (2017)

PTEN interacts with the transcription machinery on chromatin and regulates RNA polymerase II-mediated transcription
por: Steinbach, Nicole, et al.
Publicado: (2019)

Differential requirement of a distal regulatory region for pre-initiation complex formation at globin gene promoters
por: Ross, Julie, et al.
Publicado: (2009)

Recruitment of MBD1 to target genes requires sequence-specific interaction of the MBD domain with methylated DNA
por: Clouaire, Thomas, et al.
Publicado: (2010)

The chromatin remodeller CHD8 is required for E2F-dependent transcription activation of S-phase genes
por: Subtil-Rodríguez, Alicia, et al.
Publicado: (2014)

The KDM5 family is required for activation of pro-proliferative cell cycle genes during adipocyte differentiation
por: Brier, Ann-Sofie B., et al.
Publicado: (2017)

BRD4 promotes p63 and GRHL3 expression downstream of FOXO in mammary epithelial cells
por: Nagarajan, Sankari, et al.
Publicado: (2017)

Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters
por: Ni, Weiya, et al.
Publicado: (2020)

Higher order oligomerization is required for H-NS family member MvaT to form gene-silencing nucleoprotein filament
por: Winardhi, Ricksen S., et al.
Publicado: (2012)

Sin3a–Tet1 interaction activates gene transcription and is required for embryonic stem cell pluripotency
por: Zhu, Fugui, et al.
Publicado: (2018)

Core binding factor (CBF) is required for Epstein-Barr virus EBNA3 proteins to regulate target gene expression
por: Paschos, Kostas, et al.
Publicado: (2017)

Spt6 directly interacts with Cdc73 and is required for Paf1 complex occupancy at active genes in Saccharomyces cerevisiae
por: Ellison, Mitchell A, et al.
Publicado: (2023)

Dissecting the function of the adult β-globin downstream promoter region using an artificial zinc finger DNA-binding domain
por: Barrow, Joeva J., et al.
Publicado: (2014)

USP10 deubiquitylates the histone variant H2A.Z and both are required for androgen receptor-mediated gene activation
por: Draker, Ryan, et al.
Publicado: (2011)

Requirement for PRC1 subunit BMI1 in host gene activation by Epstein–Barr virus protein EBNA3C
por: Paschos, Kostas, et al.
Publicado: (2019)

The histone H3K36 demethylase Rph1/KDM4 regulates the expression of the photoreactivation gene PHR1
por: Liang, Chung-Yi, et al.
Publicado: (2011)

The hematopoietic regulator TAL1 is required for chromatin looping between the β-globin LCR and human γ-globin genes to activate transcription
por: Yun, Won Ju, et al.
Publicado: (2014)

hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling
por: Roy, Rajat, et al.
Publicado: (2014)

SAC3B, a central component of the mRNA export complex TREX-2, is required for prevention of epigenetic gene silencing in Arabidopsis
por: Yang, Yu, et al.
Publicado: (2017)

Cyclin-dependent kinase 1 activity coordinates the chromatin associated state of Oct4 during cell cycle in embryonic stem cells
por: Kim, Hye Ji, et al.
Publicado: (2018)

Evidence of efficient stop codon readthrough in four mammalian genes
por: Loughran, Gary, et al.
Publicado: (2014)

Genome-wide co-localization of active EGFR and downstream ERK pathway kinases mirrors mitogen-inducible RNA polymerase 2 genomic occupancy
por: Mikula, M., et al.
Publicado: (2016)

Sas3 and Ada2(Gcn5)-dependent histone H3 acetylation is required for transcription elongation at the de-repressed FLO1 gene
por: Church, Michael, et al.
Publicado: (2017)

Mechanism of REST/NRSF regulation of clustered protocadherin α genes
por: Tang, Yuanxiao, et al.
Publicado: (2021)

AUF1 p42 isoform selectively controls both steady-state and PGE(2)-induced FGF9 mRNA decay
por: Chen, Tsung-Ming, et al.
Publicado: (2010)

The core-independent promoter-specific interaction of primary sigma factor
por: Yeh, Hsin-Yi, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_jin2osph1us25j4d4ejui6tif2