Structure-Guided, Single-Point Modifications in the Phosphinic Dipeptide Structure Yield Highly Potent and Selective Inhibitors of Neutral Aminopeptidases

[Image: see text] Seven crystal structures of alanyl aminopeptidase from Neisseria meningitides (the etiological agent of meningitis, NmAPN) complexed with organophosphorus compounds were resolved to determine the optimal inhibitor–enzyme interactions. The enantiomeric phosphonic acid analogs of Leu...

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Detalles Bibliográficos
Autores principales: Vassiliou, Stamatia, Węglarz-Tomczak, Ewelina, Berlicki, Łukasz, Pawełczak, Małgorzata, Nocek, Bogusław, Mulligan, Rory, Joachimiak, Andrzej, Mucha, Artur
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331105/
https://www.ncbi.nlm.nih.gov/pubmed/25192493
http://dx.doi.org/10.1021/jm501071f

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331105/
https://www.ncbi.nlm.nih.gov/pubmed/25192493
http://dx.doi.org/10.1021/jm501071f

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