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HZ08 Reverse P-Glycoprotein Mediated Multidrug Resistance In Vitro and In Vivo
BACKGROUND: Multidrug efflux transporter P-glycoprotein (P-gp) is highly expressed on membrane of tumor cells and is implicated in resistance to tumor chemotherapy. HZ08 is synthesized and studied in order to find a novel P-gp inhibitor. METHODS: MDCK-MDR1 monolayer transport, calcein-AM P-gp inhibi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331368/ https://www.ncbi.nlm.nih.gov/pubmed/25689592 http://dx.doi.org/10.1371/journal.pone.0116886 |