The Acetate/ACSS2 Switch Regulates HIF-2 Stress Signaling in the Tumor Cell Microenvironment

Optimal stress signaling by Hypoxia Inducible Factor 2 (HIF-2) during low oxygen states or hypoxia requires coupled actions of a specific coactivator/lysine acetyltransferase, Creb binding protein (CBP), and a specific deacetylase, Sirtuin 1 (SIRT1). We recently reported that acetylation of HIF-2 by...

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Detalles Bibliográficos
Autores principales: Chen, Rui, Xu, Min, Nagati, Jason S., Hogg, Richard T., Das, Alok, Gerard, Robert D., Garcia, Joseph A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331492/
https://www.ncbi.nlm.nih.gov/pubmed/25689462
http://dx.doi.org/10.1371/journal.pone.0116515

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331492/
https://www.ncbi.nlm.nih.gov/pubmed/25689462
http://dx.doi.org/10.1371/journal.pone.0116515

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