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The Acetate/ACSS2 Switch Regulates HIF-2 Stress Signaling in the Tumor Cell Microenvironment

Optimal stress signaling by Hypoxia Inducible Factor 2 (HIF-2) during low oxygen states or hypoxia requires coupled actions of a specific coactivator/lysine acetyltransferase, Creb binding protein (CBP), and a specific deacetylase, Sirtuin 1 (SIRT1). We recently reported that acetylation of HIF-2 by...

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Detalles Bibliográficos
Autores principales:	Chen, Rui, Xu, Min, Nagati, Jason S., Hogg, Richard T., Das, Alok, Gerard, Robert D., Garcia, Joseph A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331492/ https://www.ncbi.nlm.nih.gov/pubmed/25689462 http://dx.doi.org/10.1371/journal.pone.0116515

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