Cargando…
The Acetate/ACSS2 Switch Regulates HIF-2 Stress Signaling in the Tumor Cell Microenvironment
Optimal stress signaling by Hypoxia Inducible Factor 2 (HIF-2) during low oxygen states or hypoxia requires coupled actions of a specific coactivator/lysine acetyltransferase, Creb binding protein (CBP), and a specific deacetylase, Sirtuin 1 (SIRT1). We recently reported that acetylation of HIF-2 by...
Autores principales: | Chen, Rui, Xu, Min, Nagati, Jason S., Hogg, Richard T., Das, Alok, Gerard, Robert D., Garcia, Joseph A. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331492/ https://www.ncbi.nlm.nih.gov/pubmed/25689462 http://dx.doi.org/10.1371/journal.pone.0116515 |
Ejemplares similares
-
Coordinate regulation of stress signaling and epigenetic events by Acss2 and HIF-2 in cancer cells
por: Chen, Rui, et al.
Publicado: (2017) -
Correction: The Acetate/ACSS2 Switch Regulates HIF-2 Stress Signaling in the Tumor Cell Microenvironment
Publicado: (2015) -
Acss2/HIF-2 signaling facilitates colon cancer growth and metastasis
por: Garcia, Joseph A., et al.
Publicado: (2023) -
A mammalian acetate switch regulates stress erythropoiesis
por: Xu, Min, et al.
Publicado: (2014) -
A substitution mutation in a conserved domain of mammalian acetate-dependent acetyl CoA synthetase 2 results in destabilized protein and impaired HIF-2 signaling
por: Nagati, Jason S., et al.
Publicado: (2019)