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I–J loop involvement in the pharmacological profile of CLC-K channels expressed in Xenopus oocytes
CLC-K chloride channels and their subunit, barttin, are crucial for renal NaCl reabsorption and for inner ear endolymph production. Mutations in CLC-Kb and barttin cause Bartter syndrome. Here, we identified two adjacent residues, F256 and N257, that when mutated hugely alter in Xenopus oocytes CLC-...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Pub. Co
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331650/ https://www.ncbi.nlm.nih.gov/pubmed/25073071 http://dx.doi.org/10.1016/j.bbamem.2014.07.021 |