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The replicometer is broken: telomeres activate cellular senescence in response to genotoxic stresses
Telomeres, the ends of our linear chromosomes, can function as ‘replicometers’, capable of counting cell division cycles as they progressively erode with every round of DNA replication. Once they are critically short, telomeres become dysfunctional and consequently activate a proliferative arrest ca...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BlackWell Publishing Ltd
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4331758/ https://www.ncbi.nlm.nih.gov/pubmed/25040628 http://dx.doi.org/10.1111/acel.12246 |