Hepatocytes maintain greater fluorescent bile acid accumulation and greater sensitivity to drug‐induced cell death in three‐dimensional matrix culture

Primary hepatocytes undergo phenotypic dedifferentiation upon isolation from liver that typically includes down regulation of uptake transporters and up regulation of efflux transporters. Culturing cells between layers of collagen in a three‐dimensional (3D) “sandwich” is reported to restore hepatic...

Descripción completa

Detalles Bibliográficos
Autores principales: Murray, John W., Han, Dennis, Wolkoff, Allan W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wiley Periodicals, Inc. 2014
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332201/
https://www.ncbi.nlm.nih.gov/pubmed/25524275
http://dx.doi.org/10.14814/phy2.12198

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332201/
https://www.ncbi.nlm.nih.gov/pubmed/25524275
http://dx.doi.org/10.14814/phy2.12198

Ejemplares similares