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Hepatocytes maintain greater fluorescent bile acid accumulation and greater sensitivity to drug‐induced cell death in three‐dimensional matrix culture
Primary hepatocytes undergo phenotypic dedifferentiation upon isolation from liver that typically includes down regulation of uptake transporters and up regulation of efflux transporters. Culturing cells between layers of collagen in a three‐dimensional (3D) “sandwich” is reported to restore hepatic...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Wiley Periodicals, Inc.
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332201/ https://www.ncbi.nlm.nih.gov/pubmed/25524275 http://dx.doi.org/10.14814/phy2.12198 |