Cargando…

F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse

Integrin-dependent interactions between T cells and antigen-presenting cells are vital for proper T cell activation, effector function, and memory. Regulation of integrin function occurs via conformational change, which modulates ligand affinity, and receptor clustering, which modulates valency. Her...

Descripción completa

Detalles Bibliográficos
Autores principales: Comrie, William A., Babich, Alexander, Burkhardt, Janis K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332248/
https://www.ncbi.nlm.nih.gov/pubmed/25666810
http://dx.doi.org/10.1083/jcb.201406121