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F-actin flow drives affinity maturation and spatial organization of LFA-1 at the immunological synapse
Integrin-dependent interactions between T cells and antigen-presenting cells are vital for proper T cell activation, effector function, and memory. Regulation of integrin function occurs via conformational change, which modulates ligand affinity, and receptor clustering, which modulates valency. Her...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332248/ https://www.ncbi.nlm.nih.gov/pubmed/25666810 http://dx.doi.org/10.1083/jcb.201406121 |