Down Regulation of the TCR Complex CD3ζ-Chain on CD3+ T Cells: A Potential Mechanism for Helminth-Mediated Immune Modulation

The CD3ζ forms part of the T cell receptor (TCR) where it plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways leading to T cell effector functions. Down regulation of CD3ζ leads to impairment of immune responses including reduced cell prolife...

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Detalles Bibliográficos
Autores principales: Appleby, Laura J., Nausch, Norman, Heard, Francesca, Erskine, Louise, Bourke, Claire D., Midzi, Nicholas, Mduluza, Takafira, Allen, Judith E., Mutapi, Francisca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332365/
https://www.ncbi.nlm.nih.gov/pubmed/25741337
http://dx.doi.org/10.3389/fimmu.2015.00051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4332365/
https://www.ncbi.nlm.nih.gov/pubmed/25741337
http://dx.doi.org/10.3389/fimmu.2015.00051

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