Coordinated gripping of substrate by subunits of a AAA+ proteolytic machine

Hexameric AAA+ unfoldases of ATP-dependent proteases and protein-remodeling machines use conserved loops that line the axial pore to apply force to substrates during the mechanical processes of protein unfolding and translocation. Whether loops from multiple subunits act independently or coordinatel...

Descripción completa

Detalles Bibliográficos
Autores principales: Iosefson, Ohad, Nager, Andrew R., Baker, Tania A., Sauer, Robert T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333055/
https://www.ncbi.nlm.nih.gov/pubmed/25599533
http://dx.doi.org/10.1038/nchembio.1732

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333055/
https://www.ncbi.nlm.nih.gov/pubmed/25599533
http://dx.doi.org/10.1038/nchembio.1732

Ejemplares similares