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Coordinated gripping of substrate by subunits of a AAA+ proteolytic machine
Hexameric AAA+ unfoldases of ATP-dependent proteases and protein-remodeling machines use conserved loops that line the axial pore to apply force to substrates during the mechanical processes of protein unfolding and translocation. Whether loops from multiple subunits act independently or coordinatel...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333055/ https://www.ncbi.nlm.nih.gov/pubmed/25599533 http://dx.doi.org/10.1038/nchembio.1732 |