Tonic 5nM DA Stabilizes Neuronal Output by Enabling Bidirectional Activity-Dependent Regulation of the Hyperpolarization Activated Current via PKA and Calcineurin

Volume transmission results in phasic and tonic modulatory signals. The actions of tonic dopamine (DA) at type 1 DA receptors (D1Rs) are largely undefined. Here we show that tonic 5nM DA acts at D1Rs to stabilize neuronal output over minutes by enabling activity-dependent regulation of the hyperpola...

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Detalles Bibliográficos
Autores principales: Krenz, Wulf-Dieter C., Rodgers, Edmund W., Baro, Deborah J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333293/
https://www.ncbi.nlm.nih.gov/pubmed/25692473
http://dx.doi.org/10.1371/journal.pone.0117965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333293/
https://www.ncbi.nlm.nih.gov/pubmed/25692473
http://dx.doi.org/10.1371/journal.pone.0117965

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