DNA ligase III acts as a DNA strand break sensor in the cellular orchestration of DNA strand break repair

In the current model of DNA SSBR, PARP1 is regarded as the sensor of single-strand breaks (SSBs). However, biochemical studies have implicated LIG3 as another possible SSB sensor. Using a laser micro-irradiation protocol that predominantly generates SSBs, we were able to demonstrate that PARP1 is di...

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Detalles Bibliográficos
Autores principales: Abdou, Ismail, Poirier, Guy G., Hendzel, Michael J., Weinfeld, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333375/
https://www.ncbi.nlm.nih.gov/pubmed/25539916
http://dx.doi.org/10.1093/nar/gku1307

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4333375/
https://www.ncbi.nlm.nih.gov/pubmed/25539916
http://dx.doi.org/10.1093/nar/gku1307

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